29. Enhancement Tumor Immunity-Modification of Autochthonous Antigen with Mercaptounadecahydroduodecaborate

The novel vaccine contained full tumor antigen hopeful to solve the problems of antigen delivery and host immunity enhancement

Herein, we report for the first time of the novel vaccine cell composed with allogenic mature dendritic cells (DCs) and inactive gastric cancer (GC) cells prepared by PEG mediated fusion. Combined with effecter of cytokine induced killing cells (CIKs), the immunotherapeutic and prophylactic potential of the fused vaccine cells (VCs) were evaluated in tumor-bearing, post-surgery and tumor free m...

Antigen-Specific Immunity in Lack of Effective MUC1 Tumor

Improved generation of anti-tumor immunity by antigen dose limitation

BACKGROUND The malignant cells of cutaneous T cell lymphoma (CTCL) display immunogenic peptides derived from the clonal T cell receptor (TCR) providing an attractive model for refinement of anti-tumor immunization methodology. To produce a clinically meaningful anti-tumor response, induction of cytotoxic anti-CTCL cells must be maximized while suppressive T regulatory cells (Treg) should be min...

Lymphatic dysfunction attenuates tumor immunity through impaired antigen presentation

Tumor growth and metastasis of cancer involve autonomous tumor cell growth and host-tumor interactions. While tumor-specific immunity has been intensively studied in vitro, dynamic roles of lymphatic transport on tumor immunity in vivo have not been fully elucidated. In this study, we examined tumor growth and anti-tumor immune responses using kCYC mice, which demonstrate severe lymphatic dysfu...

Immune complex-mediated antigen presentation induces tumor immunity.

Antigen uptake receptors on dendritic cells (DCs) provide efficient entry for the initiation of antigen-specific adaptive immunity. Here we show that targeting of antigen to Fc receptors on DCs accomplishes combined activation of Th1 CD4 and CD8 effector responses in vivo, namely delayed-type hypersensitivity and tumor immunity. Tumor immunity specific for ovalbumin-expressing tumors was provid...